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Deficiencies in the repair of DNA are..
Matthew Schiewer, PhD:
Thomas Jefferson University
Mentor:
Karen Knudsen, PhD
Project Title:
Determining the translation capacity of the PARP-1/AR axis in prostate cancer
Dr. Efsathiou earned both MD and PhD..
Eleni Efstathiou, MD, PhD:
The University of Texas MD Anderson Cancer Center – Houston, TX
Low vitamin D levels in blood have..
Jennifer Rider, ScD:
Harvard School of Public Health
Mentors:
Lorelei Mucci, ScD and Myles Brown, MD
Project Title:
The immunomodulatory and androgen-associated actions of vitamin D in prostate cancer
Colin Pritchard, MD, PhD:
University of Washington
Mentors:
Peter Nelson, MD
Project Title:
Targeting the ‘Hypermutated Subtype’ of Prostate Cancer: From Mechanism to Implementation of Genomic Testing for Precision Therapy”
Dr. Dehm completed a BS and PhD..
Scott M. Dehm, PhD:
Masonic Cancer Center, University of Minnesota – Minneapolis, MN
Dr. Choudhury earned a BA in Chemistry..
Atish Dipankar Choudhury, MD, PhD:
Dana-Farber Cancer Institute – Boston, MA
Dr. Bismar earned an MD degree from..
Tarek Bismar, MD:
University of Calgary – Canada
Dr. Attard earned an MD degree from..
Gerhardt Attard, MD, PhD:
The Institute for Cancer Research – London, UK
Dr. Arredouani earned a BS Degree in..
Mohamed S. Arredouani, PhD:
Beth Israel Deaconess Hospital – Boston, MA
Systems biology is a computational-based inter-disciplinary field..
Antonina Mitrofanova, PhD:
Rutgers, The State University of New Jersey
Mentor:
Michael Shen, PhD
Project Title:
A systems biology approach to identify and evaluate novel drug targets for aggressive prostate cancer
LncRNAs (long non-coding RNAs) are a form..
Rohit Mehra, MD:
University of Michigan School of Medicine
Mentor:
Arul Chinnaiyan, MD, PhD
Project Title:
Clinicopathological characterization of novel lncRNAs in prostate cancer risk stratification
Differentiating indolent from aggressive prostate tumors is..
Marcin Cieslik, PhD:
University of Michigan
Mentor:
Arul Chinnaiyan, MD, PhD
Proposal Title:
Clinical Implications of Expressed Pseudogene Transcripts in Metastatic Castration-Resistant Prostate Cancer
Certain oncogenic molecules in prostate cancer cells..
Theodoros Karantanos, MD:
MD Anderson Cancer Center
Mentors:
Timothy Thompson, PhD and Christopher Logothetis, MD
Project Title:
The role of aerobic glycolysis in the development of castrate resistant prostate cancer
T cells are a type of immune..
W. Nathaniel Brennen, PhD:
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Mentors:
John Isaacs, PhD, Charles Drake, MD, PhD
Proposal Title:
T cells Engineered to Selectively Deliver a PSA-activated Protoxin to Sites of Advanced Prostate Cancer
Dr. Armstrong earned a BS in Biomedical..
Andrew Armstrong, MD, ScM:
Duke University – Durham, NC
Preclinical assessment of mechanisms of resistance to..
Vivek Arora, MD, PhD:
Washington University
Mentor:
Charles Sawyers, MD
Project Title:
Defining strategies to overcome enzalutamide (Xtandi) resistance
Approximately 25% of patients who fail Xtandi..
Jennifer Bishop, PhD:
University of British Columbia
Mentors:
Martin Gleave, MD and Amina Zoubeidi, PhD
Project Title:
Regulation of cell plasticity by the androgen receptor: A novel mechanism of enzalutamide (Xtandi) resistance
The organization of DNA into super-structures is..
Irfan Asangani, PhD:
University of Michigan
Mentor:
Arul Chinnaiyan, MD, PhD
Project Title:
Characterization and therapeutic targeting of MMSET in prostate cancer
Engraftment of prostate cancer in bone heralds..
Charles Chan, PhD:
Stanford University School of Medicine
Mentors:
Irving Weissman, MD and Michael Longaker, MD
Project Title:
Identification and therapeutic targeting of cancer stem cell niche interactions in metastatic prostate bone marrow disease
An unmet medical need is the control..
Chia-Yi Chu, PhD:
Cedars-Sinai Medical Center
Mentor:
Leland Chung, PhD
Project Title:
Metastasis-initiating cells (MICs) as predictors of lethal progression of human prostate cancer
Molecular imaging of prostate cancer to determine..
Michael Evans, PhD:
University of California, San Francisco
Mentors:
Charles Sawyers, MD and Jason Lewis, PhD
Project Title:
Exploiting the genetics of advanced prostate cancer for tumor detection and therapy with transferrin-based radionuclides
Jason A. Efstathiou, MD, DPhil:
Massachusetts General Hospital
Mentor:
Matthew R. Smith, MD, PhD
Project Title:
Predictors of Response and Failure to Radiotherapy for Prostate Cancer in a Randomized Trial
Proteomics is the study of proteins in..
Geraldine Gueron, PhD:
Iquibicen-Conicet (Argentina)
Mentor:
Elba Vazquez, PhD
Project Title:
Proteome-base biomarkers in prostate cancer: protein profiling using mass spectrometry, bioinformatics based approach and tissue microarray technology
Immunotherapy has come of age with the..
Mentors:
Philip Kantoff, MD and Christopher Sweeney, MBBS
Project Title:
Clinical exploration of innovative targeted and immune modulating therapies in prostate cancer
Understanding resistance to new treatments for advanced,..
Emmanuel Antonarakis, MD:
Johns Hopkins University School of Medicine
Mentors:
Michael Carducci, MD and Jun Luo, PhD
Project Title:
Understanding mechanisms of response and resistance to abiraterone (Zytiga) and enzalutamide (Xtandi) in men with metastatic castration-resistant prostate cancer, by interrogation of tumor biopsies for androgen receptor splice variants.
Over 1 million prostate biopsies are performed..
Syed Adnan Ali, MD:
Mount Sinai School of Medicine
Mentor:
Ashutosh Tewari, MD
Project Title:
Intratumor Heterogeneity (ITH) in Prostate Cancer
Long non-coding RNAs (lncRNAs) such as PCAT1..
Institution:
University of Michigan
Mentors:
Arul Chinnaiyan, MD, PhD; Felix Feng, MD
Proposal Title:
Investigating Long Noncoding RNAs in Aggressive Prostate Cancer
Next generation sequencing (NGS) is a growing..
Rendong Yang, PhD:
University of Minnesota
Mentor:
Scott Dehm, PhD
Proposal Title:
Delineating Coding and Regulatory Indels in Prostate Cancer
Genomic analysis of cancer tissue has enabled..
Adam Sowalsky, PhD:
National Cancer Institute
Mentors:
Kathleen Kelly, PhD; William Dahut, MD
Proposal Title:
Investigations into the Mechanisms of Resistance to Enzalutamide in CRPC
As life expectancy rises, greater numbers of..
Prasanna Sooriakumaran, MBBS, PhD:
University of Oxford
Mentor:
Freddie C. Hamdy, MD
Proposal Title:
Improving Quality of Care for Men with Skeletal Metastases from Prostate Cancer: Defining the Burden-of-Treatment and its Management, and Developing Models to Predict Quality-of-Life
Cancer is characterized by accumulation and loss..
Shabnam Shalapour, PhD:
University of California, San Diego
Mentor:
Michael Karin, PhD
Proposal Title:
Development of Immunosuppressive Plasmocytes that Interfere with T-Cell-Dependent Immunogenic Chemotherapy in Prostate Cancer
Supplementing a patient’s immune response by engineering..
Saul Priceman, PhD:
City of Hope National Medical Center
Mentor:
Stephen Forman, MD
Proposal Title:
Targeting Metastatic Prostate Cancer with PSA-Specific Chimeric Antigen Receptor-Engineered T-Cells
New hormonal treatments for prostate cancer such..
Sean McGuire, MD, PhD:
Baylor College of Medicine
Mentor:
Bert O’Malley, MD
Proposal Title:
Targeting the Mitochondrial Pyruvate Carrier in Castration- Resistant Prostate Cancer
Immune checkpoint inhibitors “take the brakes” off..
Ravi Madan, MD:
National Cancer Institute
Mentor:
James Gulley, MD, PhD
Proposal Title:
Using A Therapeutic Cancer Vaccine to Enhance Anti-PD-1 Therapy Prior to Prostatectomy