Jihyun Lee

About Jihyun Lee

T-cells are a type of fighter blood cells that activate a ‘killing’ mechanism in response to exposure to a foreign material such as a pathogen or new proteins on the surface of a tumor cell. Dr. Carl June at the University of Pennsylvania will generate engineered T-cells directed to kill prostate tumors. He plans to express PSMA (Prostate-Specific Membrane Antigen)-recognizing molecules on the surface of patient T-cells. If successful, the findings from this proposal will lead to the development of a cellular therapy for malignant hormone refractory prostate cancer that will destroy recurrent tumor while conferring persistent protection against newly arising PSMA-expressing tumors in patients.