Sarah Holt

About Sarah Holt

Dr. Holt earned a BA in Biology from Skidmore College, an MS in Public Health from the University of Colorado and a PhD in Epidemiology from the University of Washington. She is currently a Senior Postdoctoral Research Fellow at the Fred Hutchinson Cancer Research Center.

Carcinogenic effects of estrogen on the prostate have been demonstrated in laboratory models. Furthermore, there is a current resurgence of interest in using synthetic estrogens to treat patients with advanced prostate cancer. Dr. Holt plans to study genetic alterations in genes responsible for estrogen sensitivity and metabolism in the prostate of approximately 1,457 prostate cancer patients compared to 1,351 control subjects without prostate cancer. Results should help identify patients with increased risk for primary prostate cancer and those who might develop a more aggressive form of the disease.

Dr. Janet Stanford, an internationally-recognized prostate cancer geneticist and population scientist, will provide mentorship.