Daniel Spratt
Some prostate cancer patients who undergo radiation therapy do not derive a significant benefit from this treatment. The androgen receptor (AR) is the primary factor mediating growth and survival in...Read More
Richard Lee
Circulating Tumor Cells (CTCs) detach from metastatic tumor sites and can be isolated from patient blood specimens. CTCs are good predictors of metastatic tumor biology. Dr. Lee proposes to study...Read More
Gustavo Ayala, MD
Targeting Neurogenesis in Prostate Cancer The prostate gland is rich in nerves and proteins that support nerve growth (neural growth factors). Studies from Dr. Ayala’s group have demonstrated that prostate...Read More
Jinjun Shi
The immune system has the power to recognize and kill cells that are dangerous to host homeostasis. Vaccination against tumor antigens has appreciated limited success in inducing anti-tumor immune responses,...Read More
Jihyun Lee
T-cells are a type of fighter blood cells that activate a ‘killing’ mechanism in response to exposure to a foreign material such as a pathogen or new proteins on the...Read More
Nikolaus Schultz
Precision medicine is the generation of individualized patient treatment plans based on their unique tumor biology. A plethora of genomic, molecular, pathological, and clinical information is used to guide the...Read More
Maria Karlou
To address the challenges of resistance to therapy and cancer progression in CRPC patients, it is important to study the underlying mechanisms. Dr. Maria Karlou proposes to address these challenges...Read More
Bruce Zetter, PhD
The Mesenchymal-to-Epithelial Transition (MET) as a Novel Target for Treatment of Disseminated (Metastatic) Prostate Cancer Epithelial-mesenchymal transition (EMT) is a programmed loss of cell adhesion accompanied by increased cell motility...Read More
Anirban Sahu
Long non-coding RNAs (lncRNA) are a recently appreciated class of RNA molecules that are transcribed from exons in the genome, but are not translated into proteins. Some lncRNAs are differentially...Read More
Corinne Joshu
Dr. Joshu and colleagues previously observed that men who gained weight circa the time of prostatectomy were twice as likely to recur as compared with men who maintained their weight....Read More