Bone Health Medicines

Bones are the most common site of prostate cancer metastasis, occurring in 85%–90% of patients with metastatic prostate cancer. Bone metastases interfere with the bone’s normal health and strength. If they grow large enough, they can lead to bone pain, fracture, or other complications that can significantly impair a patient’s health.

Treatment with medicines called bisphosphonates (zoledronic acid; Zometa®) or denosumab (Xgeva®) can help prevent complications related to bone metastases. Risks with these drugs include osteonecrosis of the jaw, which is rare, but can result in jaw pain and poor healing of your teeth. Your doctor will monitor certain lab values regularly. Typically, your doctor will also recommend a thorough dental exam prior to starting these agents. Discuss the need for calcium and vitamin D supplements with your doctor.

Last Reviewed: 12/2023