Advanced Prostate Cancer Treatment Many more treatment options for advanced disease have become available in recent years, and doctors are learning how to better use existing treatments. Metastatic Hormone-Sensitive Disease Hormone-Resistant Prostate Cancer Hormone Therapy Androgen Receptor Pathway Inhibitors Chemotherapy Sipuleucel-T Pembrolizumab PSMA Radionuclide Therapy Radium-223 PARP Inhibitors External Beam Radiation Therapy Bone Health Medicines From Crippling Bone Pain to Long-Term Remission Learn More