Matthew Schiewer

About Matthew Schiewer

• Deficiencies in the repair of DNA are a hallmark of cancer. A molecule, named PARP, is involved in DNA damage repair. The inhibition of PARP with specific medications is a potential therapy for advanced, metastatic prostate cancer.
• Inhibition of PARP may also reduce cancer progression by reducing the activity of the androgen receptor which is the engine of prostate cancer.
• In these investigations, Dr. Schiewer will study the role of PARP in the modulation of AR activity.

What this means to patients: Understanding the relationship between PARP inhibition and AR activity may provide new therapeutic opportunities for prostate cancer patients with advanced, metastatic disease.